Publications

Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

He, Nianzhe ; Depta, Laura ; Rossetti, Cecilia ; Caramelle, Lucie ; Cigler, Marko ; Bryce-Rogers, Hogan P. ; Michon, Marine ; Rafn Dan, Oliver ; Hoock, Joseph ; Barbier, Julien ; Gillet, Daniel ; Forrester, Alison ; Winter, Georg E. ; Laraia, Luca
in: Nature Chemical Biology

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2025 | DOI: https://doi.org/10.1038/s41589-024-01653-x

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP

Cigler, Marko ; Imrichova, Hana ; Frommelt, Fabian ; Caramelle, Lucie ; Depta, Laura ; Rukavina, Andrea ; Kagiou, Chrysanthi ; Hannich, J. Thomas ; Mayor-Ruiz, Cristina ; Superti-Furga, Giulio ; Sievers, Sonja ; Forrester, Alison ; Laraia, Luca ; Waldmann, Herbert ; Winter, Georg E.
in: Nature Chemical Biology

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2025 | DOI: https://doi.org/10.1038/s41589-024-01614-4

Fluorescent probes and degraders of the sterol transport protein Aster-A

He, Nianzhe ; Depta, Laura ; Sievers, Sonja ; Laraia, Luca
in: Bioorganic and Medicinal Chemistry, vol: 103

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1016/j.bmc.2024.117673

Sphingomyelin complexed cholesterol controls Lymphocyte function-associated antigen-1 mediated effector T cell function

Patommel, K. A. ; Marti i Lindez, A. A. ; Jaenicke, J. ; Verma, S. ; Edwards-Hicks, J. ; Hess, C. ; Laraia, L. ; Wilson, S. ; Donde, M. ; Lötscher, J. ; Booty, L. M.
in: Swiss Medical Weekly, vol: 154, issue: P11, pages: 16S-16S
Presented at: SSAI Annual Congress 2024

Type: Conference abstract in journal (Peer reviewed)

Status: Published | Year: 2024

Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

Yao, Ruwei ; Jensen, Anders A. ; Bryce-Rogers, Hogan P. ; Schultz-Knudsen, Katrine ; Zhou, Libin ; Hovendal, Nicklas P. ; Pedersen, Henrik ; Kubus, Mariusz ; Ulven, Trond ; Laraia, Luca
in: Journal of Medicinal Chemistry, vol: 66, issue: 16, pages: 11536-11554

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1021/acs.jmedchem.3c01059

Identification of biologically diverse tetrahydronaphtalen‐2‐ols through the synthesis and phenotypic profiling of chemically diverse, estradiol‐inspired compounds

Whitmarsh-Everiss, Thomas ; Wang, Zhou ; Hansen, Cecilie Hauberg ; Depta, Laura ; Sassetti, Elisa ; Dan, Oliver Rafn ; Pahl, Axel ; Sievers, Sonja ; Laraia, Luca
in: ChemBioChem, vol: 24, issue: 5

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1002/cbic.202200555

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Hoock, Joseph G.F. ; Rossetti, Cecilia ; Bilgin, Mesut ; Depta, Laura ; Enemark-Rasmussen, Kasper ; Christianson, John C. ; Laraia, Luca
in: Chemical Science, vol: 14, issue: 45

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1039/d3sc04064j

Making bubbles

Dekker, Nienke Julia ; Laraia, Luca
in: Cell Chemical Biology, vol: 30, issue: 2, pages: 127-129

Type: Comment/debate (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1016/j.chembiol.2023.01.008

Redshifted and thermally bistable one-way quantitative hemithioindigo-derived photoswitches enabled by isomer-specific excited state intramolecular proton transfer

Krell-Jørgensen, Mikkel ; Zulfikri, Habiburrahman ; Bonnevie, Magnus Grage ; Bro, Frederik Simonsen ; Dohn, Asmus Ougaard ; Laraia, Luca
in: Chemical Communications, vol: 59, pages: 563-566

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1039/d2cc05548a

A photochemical microfluidic reactor for photosensitized [2+2] cycloadditions

Bargum, Martin A ; Krell-Jørgensen, Mikkel P ; Nielsen, Martin ; Qvortrup, Katrine ; Laraia, Luca
in: Synlett, vol: 33

Type: Letter (Peer reviewed)

Status: Published | Year: 2022 | DOI: https://doi.org/10.1055/a-1771-4883

Publikationer