G-protein coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins known to date.
GPCRs are potential drug targets. Among the GPCRs, we will primarily focus on receptors in the central nervous system, whos structures are not available yet.
We are particularly interested in:
- constructing model structures of these receptors using computational methods.
- getting detailed insight into the conformational changes induced by agonist vs. antagonist.
- guiding the design of potential drugs.