The interactions between bile salts and cyclodextrins (CDs: macrocyclic oligosugars) are of importance for the release of CD-complexed drugs upon oral administration.
We are particularly interested in:
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To understand the key interactions that drive complexation and essential. This knowledge is essential for rational drug formulation.
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To unravel the role of dehydration of the compounds during complexation for stability of the complex – i.e. to elucidate the role of the hydrophobic effect.