hemistry is essential in our society and plays a fundamental role in all aspects of our lives, from our necessities like food and clothing to life-saving medicine. The basis of organic chemistry and the synthesis of organic molecules like pharmaceuticals lies in the coupling of carbon atoms. The development of novel C-C bond forming protocols and improvement of existing methodologies constitutes an imperative endeavor for the chemical industry and society. In this thesis two novel, transition metal-catalyzed, C-C bond forming methodologies have been developed, both functionalizing a C(sp3 )-H bond directly. Additionally, a chiral nickel catalyst has been incorporated into a polystyrene matrix. The incorporation in polystyrene makes the catalyst recyclable, without compromising its catalytic properties, and suitable for carrying out a C-C bond forming reaction in a continuous flow setup. The heterogenization methodology constitutes a simple procedure to upgrade already existing catalytic systems.